The atmosphere at Fenway Park was electric on Friday night — at least until Red Sox manager Alex Cora summoned righty Greg Weissert from the bullpen in the sixth inning, and the reliever promptly coughed up the two-run lead Boston hitters had built against National League Cy Young favorite Paul Skenes, in support of Red Sox top mound prospect Payton Tolle.

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The 22-year-old Tolle was called up from Triple-A Worcester on Thursday after a meteoric rise through the Red Sox farm system. Drafted in the second round, 50th overall, last year out of TCU, the physically imposing, 6-foot-6, 250-pound lefty debuted at the Single-A level in April.

After just 18 minor league starts, Tolle made his MLB debut against the Pittsburgh Pirates on Friday, and arguably out-pitched the 23-year-old Skenes who was the No. 1 overall draft pick in 2023.

For the first five innings, certainly, Tolle got the better of Skenes. He allowed no runs on one hit with eight strikeouts and two walks. Skenes allowed an unearned run in the fourth.

In the fifth inning, Red Sox rookie sensation and former No. 1 overall prospect in MLB Roman Anthony turned on 98.8 mph fastball from Skenes, blasting it for a 408-foot home run to right field.

Skenes lasted six full innings, with Red Sox batters reaching him for seven hits, tying his career high. He struck out six and walked just one in allowing his two runs, with only one earned.

Tolle ran into trouble in the sixth, appearing to cut back on use of his fastball which topped out at 99 mph earlier in the game. After allowing back-to-back singles with one out, Cora went to the mound, calling for Weissert to relieve the rookie, who had thrown 84 pitches, 53 for strikes.

Weissert immediately surrendered a double to Pirates outfielder Tommy Pham, driving in both baserunners, tying the game and guaranteeing Tolle a no-decision for his big league debut.

Both runs were charged to Tolle.

Weissert then allowed another double, this one to veteran Andrew McCutcheon, scoring Pham giving Pittsburgh the lead — and deflating the sellout Fenway crowd of 36,344 which to that point had been at a fever pitch.

Reliever Jordan Hicks allowed a fourth run in the eighth inning.

After the game, Tolle said that “it was just the greatest experience of my life.”

“Chills, a lot of chills,” he said in the postgame press conference. “Tried to get out there a little early to take it in, just everything that I could. But it was incredible. I came off the mound after the first and I couldn’t feel my feet.”

The Red Sox ended up losing the game 4-2, thanks to the rare meltdown by the bullpen that had the lowest ERA in the American League (3.37) and second-lowest opponent’s batting average (.224).

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